Anna Niarakis

DigiDermA: Modeling Cellular and Molecular Interactions in Atopic Dermatitis

We analyzed publicly available single-cell RNA sequencing data (GEO accession GSE147424) derived from human skin biopsies of lesional and non-lesional atopic dermatitis samples …

Ouissem Saidi
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MetaLo: metabolic analysis of Logical models extracted from molecular interaction maps

Molecular interaction maps (MIMs) are static graphical representations depicting complex biochemical networks that can be formalized using one of the Systems Biology Graphical …

Sahar Aghakhani
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Hybrid computational modeling highlights reverse warburg effect in breast cancer-associated fibroblasts

Cancer-associated fibroblasts (CAFs) are amongst the key players of the tumor microenvironment (TME) and are involved in cancer initiation, progression, and resistance to therapy. …

Sahar Aghakhani
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A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint

Abstract Rheumatoid arthritis (RA) is a complex autoimmune disease with an unknown aetiology. However, rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) play a …

Vidisha Singh
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Metabolic Reprogramming in Rheumatoid Arthritis Synovial Fibroblasts: a Hybrid Modeling Approach

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by a highly invasive pannus formation consisting mainly of Synovial Fibroblasts (RASFs). This pannus leads to …

Sahar Aghakhani
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