Graphical Requirements for Multistationarity in Reaction Networks and their Verification in BioModels
Thomas's necessary conditions for the existence of multiple steady states in gene networks have been proved by Soulé with high generality for dynamical systems defined by differential equations. When applied to (protein) reaction networks however, those conditions do not provide information since they are trivially satisfied as soon as there is a bimolecular or a reversible reaction. Refined graphical requirements have been proposed to deal with such cases […]
Sat, Dec 1, 2018